LymphedemaV1, Main, Exploration, bibRecord, 003161

Serines in the Intracellular Tail of Podoplanin (PDPN) Regulate Cell Motility*

Identifieur interne : 003161 ( Main/Exploration ); précédent : 003160; suivant : 003162

Serines in the Intracellular Tail of Podoplanin (PDPN) Regulate Cell Motility*

Auteurs : Harini Krishnan ; Jhon A. Ochoa-Alvarez ; Yongquan Shen ; Evan Nevel ; Meenakshi Lakshminarayanan ; Mary C. Williams ; Maria I. Ramirez ; W. Todd Miller ; Gary S. Goldberg

Source :

The Journal of Biological Chemistry [ 0021-9258 ] ; 2013.

RBID : PMC:3636905

Abstract

Background: PDPN is a transmembrane receptor that promotes cell migration, but modifications that regulate its effects are not known.

Results: PKA can phosphorylate PDPN, nonphosphorylatable PDPN promotes cell migration, and phosphomimetic PDPN fails to promote cell migration.

Conclusion: PKA can phosphorylate PDPN to decrease cell migration.

Significance: PDPN effects on cell motility are important for processes including embryonic development and cancer progression.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636905

DOI: 10.1074/jbc.C112.446823
PubMed: 23530051
PubMed Central: 3636905

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
 PDPN is a transmembrane receptor that promotes cell migration, but modifications that regulate its effects are not known.</p>
<p><bold>Results:</bold>
 PKA can phosphorylate PDPN, nonphosphorylatable PDPN promotes cell migration, and phosphomimetic PDPN fails to promote cell migration.</p>
<p><bold>Conclusion:</bold>
 PKA can phosphorylate PDPN to decrease cell migration.</p>
<p><bold>Significance:</bold>
 PDPN effects on cell motility are important for processes including embryonic development and cancer progression.</p>
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<name sortKey="Lakshminarayanan, Meenakshi" sort="Lakshminarayanan, Meenakshi" uniqKey="Lakshminarayanan M" first="Meenakshi" last="Lakshminarayanan">Meenakshi Lakshminarayanan</name>
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Serines in the Intracellular Tail of Podoplanin (PDPN) Regulate Cell Motility*

Serines in the Intracellular Tail of Podoplanin (PDPN) Regulate Cell Motility*

Source :

Abstract

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